Keyword search (3,448 papers available)


Partial purification, kinetic analysis, and amino acid sequence information of a flavonol 3-O-methyltransferase from Serratula tinctoria.

Author(s): Huang TS, Anzellotti D, Dedaldechamp F, Ibrahim RK

Plant Physiol. 2004 Apr;134(4):1366-76 Authors: Huang TS, Anzellotti D, Dedaldechamp F, Ibrahim RK

Article GUID: 15084728
Effects of surfactants on rhizodegradation of oil in a contaminated soil.

Author(s): Memarian R, Ramamurthy AS

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(10):1486-90 Authors: Memarian R, Ramamurthy AS

Article GUID: 22571537
Enzymatic assay for GHB determination in forensic matrices.

Author(s): Grenier V, Huppé G, Lamarche M, Mireault P

J Anal Toxicol. 2012 Sep;36(7):523-8 Authors: Grenier V, Huppé G, Lamarche M, Mireault P

Article GUID: 22722059
Odorous gaseous emissions as influence by process condition for the forced aeration composting of pig slaughterhouse sludge.

Author(s): Blazy V, de Guardia A, Benoist JC, Daumoin M, Lemasle M, Wolbert D, Barrington S

Waste Manag. 2014 Jul;34(7):1125-38 Authors: Blazy V, de Guardia A, Benoist JC, Daumoin M, Lemasle M, Wolbert D, Barrington S

Article GUID: 24768513
Development of a particle-trap preconcentration-soft ionization mass spectrometric technique for the quantification of mercury halides in air

Author(s): Deeds DA; Ghoshdastidar A; Raofie F; Guérette ÉA; Tessier A; Ariya PA;

Measurement of oxidized mercury, Hg(II), in the atmosphere poses a significant analytical challenge as Hg(II) is present at ultra-trace concentrations (picograms per cubic meter air). Current technologies are sufficiently sensitive to measure the total Hg p...

Article GUID: 25837315
Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.

Author(s): Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI

Cell Cycle. 2015;14(11):1643-56 Authors: Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI

Article GUID: 25839782
Electrochemical efficacy of a carboxylated multiwalled carbon nanotube filter for the removal of ibuprofen from aqueous solutions under acidic conditions.

Author(s): Bakr AR, Rahaman MS

Chemosphere. 2016 Jun;153:508-20 Authors: Bakr AR, Rahaman MS

Article GUID: 27035389
On-chip integration of droplet microfluidics and nanostructure-initiator mass spectrometry for enzyme screening

Author(s): Joshua Heinemann

Biological assays often require expensive reagents and tedious manipulations. These shortcomings can be overcome using digitally operated microfluidic devices that require reduced sample volumes to automate assays. One particular challenge is integrating bi...

Article GUID: 27957569
Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum

Author(s): Minogianis EA; Shams WM; Mabrouk OS; Wong JT; Brake WG; Kennedy RT; du Souich P; Samaha AN;...

The faster drugs of abuse reach the brain, the greater is the risk of addiction. Even small differences in the rate of drug delivery can influence outcome. Infusing cocaine intravenously over 5 vs....

Article GUID: 29757478
Title:Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.
Authors:Beach A,  Richard VR,  Bourque S,  Boukh-Viner T,  Kyryakov P,  Gomez-Perez A,  Arlia-Ciommo A,  Feldman R,  Leonov A,  Piano A,  Svistkova V,  Titorenko VI
Link:https://www.ncbi.nlm.nih.gov/pubmed/25839782?dopt=Abstract
DOI:10.1080/15384101.2015.1026493
Category:Cell Cycle
PMID:25839782
Dept Affiliation: MASSSPEC
1 a Department of Biology; Concordia University ; Montreal , QC , Canada.

Description:

Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.

Cell Cycle. 2015;14(11):1643-56

Authors: Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI

Abstract

We have previously revealed that exogenously added lithocholic bile acid (LCA) extends the chronological lifespan of the yeast Saccharomyces cerevisiae, accumulates in mitochondria and alters mitochondrial membrane lipidome. Here, we use quantitative mass spectrometry to show that LCA alters the age-related dynamics of changes in levels of many mitochondrial proteins, as well as numerous proteins in cellular locations outside of mitochondria. These proteins belong to 2 regulons, each modulated by a different mitochondrial dysfunction; we call them a partial mitochondrial dysfunction regulon and an oxidative stress regulon. We found that proteins constituting these regulons (1) can be divided into several "clusters", each of which denotes a distinct type of partial mitochondrial dysfunction that elicits a different signaling pathway mediated by a discrete set of transcription factors; (2) exhibit 3 different patterns of the age-related dynamics of changes in their cellular levels; and (3) are encoded by genes whose expression is regulated by the transcription factors Rtg1p/Rtg2p/Rtg3p, Sfp1p, Aft1p, Yap1p, Msn2p/Msn4p, Skn7p and Hog1p, each of which is essential for longevity extension by LCA. Our findings suggest that LCA-driven changes in mitochondrial lipidome alter mitochondrial proteome and functionality, thereby enabling mitochondria to operate as signaling organelles that orchestrate an establishment of an anti-aging transcriptional program for many longevity-defining nuclear genes. Based on these findings, we propose a model for how such LCA-driven changes early and late in life of chronologically aging yeast cause a stepwise development of an anti-aging cellular pattern and its maintenance throughout lifespan.

PMID: 25839782 [PubMed - indexed for MEDLINE]