Keyword search (3,619 papers available)


Partial purification, kinetic analysis, and amino acid sequence information of a flavonol 3-O-methyltransferase from Serratula tinctoria.

Author(s): Huang TS, Anzellotti D, Dedaldechamp F, Ibrahim RK

Plant Physiol. 2004 Apr;134(4):1366-76 Authors: Huang TS, Anzellotti D, Dedaldechamp F, Ibrahim RK

Article GUID: 15084728
Effects of surfactants on rhizodegradation of oil in a contaminated soil.

Author(s): Memarian R, Ramamurthy AS

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(10):1486-90 Authors: Memarian R, Ramamurthy AS

Article GUID: 22571537
Enzymatic assay for GHB determination in forensic matrices.

Author(s): Grenier V, Huppé G, Lamarche M, Mireault P

J Anal Toxicol. 2012 Sep;36(7):523-8 Authors: Grenier V, Huppé G, Lamarche M, Mireault P

Article GUID: 22722059
Odorous gaseous emissions as influence by process condition for the forced aeration composting of pig slaughterhouse sludge.

Author(s): Blazy V, de Guardia A, Benoist JC, Daumoin M, Lemasle M, Wolbert D, Barrington S

Waste Manag. 2014 Jul;34(7):1125-38 Authors: Blazy V, de Guardia A, Benoist JC, Daumoin M, Lemasle M, Wolbert D, Barrington S

Article GUID: 24768513
Development of a particle-trap preconcentration-soft ionization mass spectrometric technique for the quantification of mercury halides in air

Author(s): Deeds DA; Ghoshdastidar A; Raofie F; Guérette ÉA; Tessier A; Ariya PA;

Measurement of oxidized mercury, Hg(II), in the atmosphere poses a significant analytical challenge as Hg(II) is present at ultra-trace concentrations (picograms per cubic meter air). Current technologies are sufficiently sensitive to measure the total Hg p...

Article GUID: 25837315
Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.

Author(s): Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI

Cell Cycle. 2015;14(11):1643-56 Authors: Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI

Article GUID: 25839782
Electrochemical efficacy of a carboxylated multiwalled carbon nanotube filter for the removal of ibuprofen from aqueous solutions under acidic conditions.

Author(s): Bakr AR, Rahaman MS

Chemosphere. 2016 Jun;153:508-20 Authors: Bakr AR, Rahaman MS

Article GUID: 27035389
On-chip integration of droplet microfluidics and nanostructure-initiator mass spectrometry for enzyme screening

Author(s): Joshua Heinemann

Biological assays often require expensive reagents and tedious manipulations. These shortcomings can be overcome using digitally operated microfluidic devices that require reduced sample volumes to automate assays. One particular challenge is integrating bi...

Article GUID: 27957569
Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum

Author(s): Minogianis EA; Shams WM; Mabrouk OS; Wong JT; Brake WG; Kennedy RT; du Souich P; Samaha AN;...

The faster drugs of abuse reach the brain, the greater is the risk of addiction. Even small differences in the rate of drug delivery can influence outcome. Infusing cocaine intravenously over 5 vs....

Article GUID: 29757478
Title:Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum
Authors:Minogianis EA,  Shams WM,  Mabrouk OS,  Wong JT,  Brake WG,  Kennedy RT,  du Souich P,  Samaha AN, 
Link:https://pubmed.ncbi.nlm.nih.gov/29757478/
DOI:10.1111/ejn.13941
Category:Eur J Neurosci
PMID:29757478
Dept Affiliation: MASSSPEC
1 Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montreal, QC, H3C 3J7, Canada.
2 Department of Psychology, Center for Studies in Behavioral Neurobiology (CSBN), Concordia University, Montreal, QC, Canada.
3 Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA.
4 Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.
5 Groupe de recherche sur le système nerveux central, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Description:

The faster drugs of abuse reach the brain, the greater is the risk of addiction. Even small differences in the rate of drug delivery can influence outcome. Infusing cocaine intravenously over 5 vs. 90-100 s promotes sensitization to the psychomotor and incentive motivational effects of the drug and preferentially recruits mesocorticolimbic regions. It remains unclear whether these effects are due to differences in how fast and/or how much drug reaches the brain. Here, we predicted that varying the rate of intravenous cocaine infusion between 5 and 90 s produces different rates of rise of brain drug concentrations, while producing similar peak concentrations. Freely moving male Wistar rats received acute intravenous cocaine infusions (2.0 mg/kg/infusion) over 5, 45 and 90 s. We measured cocaine concentrations in the dorsal striatum using rapid-sampling microdialysis (1 sample/min) and high-performance liquid chromatography-tandem mass spectrometry. We also measured extracellular concentrations of dopamine and other neurochemicals. Regardless of infusion rate, acute cocaine did not change concentrations of non-dopaminergic neurochemicals. Infusion rate did not significantly influence peak concentrations of cocaine or dopamine, but concentrations increased faster following 5-s infusions. We also assessed psychomotor activity as a function of cocaine infusion rate. Infusion rate did not significantly influence total locomotion, but locomotion increased earlier following 5-s infusions. Thus, small differences in the rate of cocaine delivery influence both the rate of rise of drug and dopamine concentrations, and psychomotor activity. A faster rate of rise of drug and dopamine concentrations might be an important issue in making rapidly delivered cocaine more addictive.