Keyword search (3,619 papers available)


Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.

Author(s): Lismer A, Dumeaux V, Lafleur C, Lambrot R, Brind'Amour J, Lorincz MC, Kimmins S

A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms remain elusive. We hypothesized that a diet that changes methyl donor availability will alter the sperm and embryo epigenomes to impact embryonic gene expression and...

Article GUID: 33596408
Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.

Author(s): Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Cell Rep. 2020 Jun 30;31(13):107838 Authors: Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Article GUID: 32610139
Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts.

Author(s): Jaju Bhattad G, Jeyarajah MJ, McGill MG, Dumeaux V, Okae H, Arima T, Lajoie P, Bérubé NG, Renaud SJ

Cell Death Dis. 2020 May 04;11(5):311 Authors: Jaju Bhattad G, Jeyarajah MJ, McGill MG, Dumeaux V, Okae H, Arima T, Lajoie P, Bérubé NG, Renaud SJ

Article GUID: 32366868
The time-varying effect of radiotherapy after breast-conserving surgery for DCIS.

Author(s): Rakovitch E, Sutradhar R, Hallett M, Thompson AM, Gu S, Dumeaux V, Whelan TJ, Paszat L

Breast Cancer Res Treat. 2019 Jul 31;: Authors: Rakovitch E, Sutradhar R, Hallett M, Thompson AM, Gu S, Dumeaux V, Whelan TJ, Paszat L

Article GUID: 31368035
Screening of Candida albicans GRACE library revealed a unique pattern of biofilm formation under repression of the essential gene ILS1.

Author(s): Costa ACBP, Omran RP, Correia-Mesquita TO, Dumeaux V, Whiteway M

Sci Rep. 2019 Jun 24;9(1):9187 Authors: Costa ACBP, Omran RP, Correia-Mesquita TO, Dumeaux V, Whiteway M

Article GUID: 31235750
Interactions between the tumor and the blood systemic response of breast cancer patients.

Author(s): Dumeaux V, Fjukstad B, Fjosne HE, Frantzen JO, Holmen MM, Rodegerdts E, Schlichting E, Børresen-Dale AL, Bongo LA, Lund E, Hallett M

PLoS Comput Biol. 2017 Sep;13(9):e1005680 Authors: Dumeaux V, Fjukstad B, Fjosne HE, Frantzen JO, Holmen MM, Rodegerdts E, Schlichting E, Børresen-Dale AL, Bongo LA, Lund E, Hallett M

Article GUID: 28957325
Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response.

Author(s): Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M

Genetics. 2019 02;211(2):579-595 Authors: Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M

Article GUID: 30530734
Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.

Author(s): Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S

Oncogene. 2019 02;38(7):1019-1037 Authors: Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S

Article GUID: 30190545
Title:Interactions between the tumor and the blood systemic response of breast cancer patients.
Authors:Dumeaux V,  Fjukstad B,  Fjosne HE,  Frantzen JO,  Holmen MM,  Rodegerdts E,  Schlichting E,  Børresen-Dale AL,  Bongo LA,  Lund E,  Hallett M
Link:https://www.ncbi.nlm.nih.gov/pubmed/28957325?dopt=Abstract
DOI:10.1371/journal.pcbi.1005680
Category:PLoS Comput Biol
PMID:28957325
Dept Affiliation: BIOLOGY
1 Department of Biology, Concordia University, Montreal, QC, Canada.
2 School of Computer Science, McGill University, Montreal, QC, Canada.
3 Department of Computer Science, UiT the Arctic University of Norway, Tromsø, Norway.
4 Department of Surgery, St. Olavs University Hospital, Trondheim, Norway.
5 Faculty of Medicine, The Norwegian University of Technology and Science, Trondheim, Norway.
6 University Hospital of North-Norway, Narvik, Norway.
7 Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
8 Nordland Central Hospital, Bodø, Norway.
9 Department of Cancer, Oslo University Hospital, Oslo, Norway.
10 Department of Cancer Genetics, Oslo University Hospital, Oslo, Norway.
11 Institute of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway.

Description:

Interactions between the tumor and the blood systemic response of breast cancer patients.

PLoS Comput Biol. 2017 Sep;13(9):e1005680

Authors: Dumeaux V, Fjukstad B, Fjosne HE, Frantzen JO, Holmen MM, Rodegerdts E, Schlichting E, Børresen-Dale AL, Bongo LA, Lund E, Hallett M

Abstract

Although systemic immunity is critical to the process of tumor rejection, cancer research has largely focused on immune cells in the tumor microenvironment. To understand molecular changes in the patient systemic response (SR) to the presence of BC, we profiled RNA in blood and matched tumor from 173 patients. We designed a system (MIxT, Matched Interactions Across Tissues) to systematically explore and link molecular processes expressed in each tissue. MIxT confirmed that processes active in the patient SR are especially relevant to BC immunogenicity. The nature of interactions across tissues (i.e. which biological processes are associated and their patterns of expression) varies highly with tumor subtype. For example, aspects of the immune SR are underexpressed proportionally to the level of expression of defined molecular processes specific to basal tumors. The catalog of subtype-specific interactions across tissues from BC patients provides promising new ways to tackle or monitor the disease by exploiting the patient SR.

PMID: 28957325 [PubMed - indexed for MEDLINE]