Keyword search (3,619 papers available)


Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.

Author(s): Lismer A, Dumeaux V, Lafleur C, Lambrot R, Brind'Amour J, Lorincz MC, Kimmins S

A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms remain elusive. We hypothesized that a diet that changes methyl donor availability will alter the sperm and embryo epigenomes to impact embryonic gene expression and...

Article GUID: 33596408
Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.

Author(s): Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Cell Rep. 2020 Jun 30;31(13):107838 Authors: Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Article GUID: 32610139
Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts.

Author(s): Jaju Bhattad G, Jeyarajah MJ, McGill MG, Dumeaux V, Okae H, Arima T, Lajoie P, Bérubé NG, Renaud SJ

Cell Death Dis. 2020 May 04;11(5):311 Authors: Jaju Bhattad G, Jeyarajah MJ, McGill MG, Dumeaux V, Okae H, Arima T, Lajoie P, Bérubé NG, Renaud SJ

Article GUID: 32366868
The time-varying effect of radiotherapy after breast-conserving surgery for DCIS.

Author(s): Rakovitch E, Sutradhar R, Hallett M, Thompson AM, Gu S, Dumeaux V, Whelan TJ, Paszat L

Breast Cancer Res Treat. 2019 Jul 31;: Authors: Rakovitch E, Sutradhar R, Hallett M, Thompson AM, Gu S, Dumeaux V, Whelan TJ, Paszat L

Article GUID: 31368035
Screening of Candida albicans GRACE library revealed a unique pattern of biofilm formation under repression of the essential gene ILS1.

Author(s): Costa ACBP, Omran RP, Correia-Mesquita TO, Dumeaux V, Whiteway M

Sci Rep. 2019 Jun 24;9(1):9187 Authors: Costa ACBP, Omran RP, Correia-Mesquita TO, Dumeaux V, Whiteway M

Article GUID: 31235750
Interactions between the tumor and the blood systemic response of breast cancer patients.

Author(s): Dumeaux V, Fjukstad B, Fjosne HE, Frantzen JO, Holmen MM, Rodegerdts E, Schlichting E, Børresen-Dale AL, Bongo LA, Lund E, Hallett M

PLoS Comput Biol. 2017 Sep;13(9):e1005680 Authors: Dumeaux V, Fjukstad B, Fjosne HE, Frantzen JO, Holmen MM, Rodegerdts E, Schlichting E, Børresen-Dale AL, Bongo LA, Lund E, Hallett M

Article GUID: 28957325
Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response.

Author(s): Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M

Genetics. 2019 02;211(2):579-595 Authors: Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M

Article GUID: 30530734
Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.

Author(s): Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S

Oncogene. 2019 02;38(7):1019-1037 Authors: Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S

Article GUID: 30190545
Title:Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts.
Authors:Jaju Bhattad G,  Jeyarajah MJ,  McGill MG,  Dumeaux V,  Okae H,  Arima T,  Lajoie P,  Bérubé NG,  Renaud SJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/32366868?dopt=Abstract
DOI:10.1038/s41419-020-2500-6
Category:Cell Death Dis
PMID:32366868
Dept Affiliation: PERFORM
1 Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
2 Department of Pediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
3 PERFORM Centre, Concordia University, Montréal, QC, Canada.
4 Department of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Sendai, Japan.
5 Department of Oncology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
6 Children's Health Research Institute, Lawson Health Research Institute, London, ON, Canada.
7 Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada. srenaud4@uwo.ca.
8 Children's Health Research Institute, Lawson Health Research Institute, London, ON, Canada. srenaud4@uwo.ca.

Description:

Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts.

Cell Death Dis. 2020 May 04;11(5):311

Authors: Jaju Bhattad G, Jeyarajah MJ, McGill MG, Dumeaux V, Okae H, Arima T, Lajoie P, Bérubé NG, Renaud SJ

Abstract

Cell fusion occurs when several cells combine to form a multinuclear aggregate (syncytium). In human placenta, a syncytialized trophoblast (syncytiotrophoblast) layer forms the primary interface between maternal and fetal tissue, facilitates nutrient and gas exchange, and produces hormones vital for pregnancy. Syncytiotrophoblast development occurs by differentiation of underlying progenitor cells called cytotrophoblasts, which then fuse into the syncytiotrophoblast layer. Differentiation is associated with chromatin remodeling and specific changes in gene expression mediated, at least in part, by histone acetylation. However, the epigenetic regulation of human cytotrophoblast differentiation and fusion is poorly understood. In this study, we found that human syncytiotrophoblast development was associated with deacetylation of multiple core histone residues. Chromatin immunoprecipitation sequencing revealed chromosomal regions that exhibit dynamic alterations in histone H3 acetylation during differentiation. These include regions containing genes classically associated with cytotrophoblast differentiation (TEAD4, TP63, OVOL1, CGB), as well as near genes with novel regulatory roles in trophoblast development and function, such as LHX4 and SYDE1. Prevention of histone deacetylation using both pharmacological and genetic approaches inhibited trophoblast fusion, supporting a critical role of this process for trophoblast differentiation. Finally, we identified the histone deacetylases (HDACs) HDAC1 and HDAC2 as the critical mediators driving cytotrophoblast differentiation. Collectively, these findings provide novel insights into the epigenetic mechanisms underlying trophoblast fusion during human placental development.

PMID: 32366868 [PubMed - in process]