Keyword search (3,171 papers available)


Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.

Author(s): Lismer A, Dumeaux V, Lafleur C, Lambrot R, Brind'Amour J, Lorincz MC, Kimmins S

A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms remain elusive. We hypothesized that a diet that changes methyl donor availability will alter the sperm and embryo epigenomes to impact embryonic gene expression and...

Article GUID: 33596408
Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.

Author(s): Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Cell Rep. 2020 Jun 30;31(13):107838 Authors: Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Article GUID: 32610139
Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts.

Author(s): Jaju Bhattad G, Jeyarajah MJ, McGill MG, Dumeaux V, Okae H, Arima T, Lajoie P, Bérubé NG, Renaud SJ

Cell Death Dis. 2020 May 04;11(5):311 Authors: Jaju Bhattad G, Jeyarajah MJ, McGill MG, Dumeaux V, Okae H, Arima T, Lajoie P, Bérubé NG, Renaud SJ

Article GUID: 32366868
The time-varying effect of radiotherapy after breast-conserving surgery for DCIS.

Author(s): Rakovitch E, Sutradhar R, Hallett M, Thompson AM, Gu S, Dumeaux V, Whelan TJ, Paszat L

Breast Cancer Res Treat. 2019 Jul 31;: Authors: Rakovitch E, Sutradhar R, Hallett M, Thompson AM, Gu S, Dumeaux V, Whelan TJ, Paszat L

Article GUID: 31368035
Screening of Candida albicans GRACE library revealed a unique pattern of biofilm formation under repression of the essential gene ILS1.

Author(s): Costa ACBP, Omran RP, Correia-Mesquita TO, Dumeaux V, Whiteway M

Sci Rep. 2019 Jun 24;9(1):9187 Authors: Costa ACBP, Omran RP, Correia-Mesquita TO, Dumeaux V, Whiteway M

Article GUID: 31235750
Interactions between the tumor and the blood systemic response of breast cancer patients.

Author(s): Dumeaux V, Fjukstad B, Fjosne HE, Frantzen JO, Holmen MM, Rodegerdts E, Schlichting E, Børresen-Dale AL, Bongo LA, Lund E, Hallett M

PLoS Comput Biol. 2017 Sep;13(9):e1005680 Authors: Dumeaux V, Fjukstad B, Fjosne HE, Frantzen JO, Holmen MM, Rodegerdts E, Schlichting E, Børresen-Dale AL, Bongo LA, Lund E, Hallett M

Article GUID: 28957325
Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response.

Author(s): Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M

Genetics. 2019 02;211(2):579-595 Authors: Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M

Article GUID: 30530734
Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.

Author(s): Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S

Oncogene. 2019 02;38(7):1019-1037 Authors: Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S

Article GUID: 30190545
Title:The time-varying effect of radiotherapy after breast-conserving surgery for DCIS.
Authors:Rakovitch E,  Sutradhar R,  Hallett M,  Thompson AM,  Gu S,  Dumeaux V,  Whelan TJ,  Paszat L
Link:https://www.ncbi.nlm.nih.gov/pubmed/31368035?dopt=Abstract
Category:Breast Cancer Res Treat
PMID:31368035
Dept Affiliation: PERFORM
1 Department of Radiation Oncology, Toronto, ON, Canada. eileen.rakovitch@sunnybrook.ca.
2 ICES, Toronto, ON, Canada. eileen.rakovitch@sunnybrook.ca.
3 Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. eileen.rakovitch@sunnybrook.ca.
4 LC Campbell Chair in Breast Cancer Research, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada. eileen.rakovitch@sunnybrook.ca.
5 ICES, Toronto, ON, Canada.
6 Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
7 Department of Biology, Concordia University, Montreal, QC, Canada.
8 School of Computer Science, McGill University, Montreal, QC, Canada.
9 Dan L Duncan Comprehensive Cancer Center, Division of Surgical, Baylor College of Medicine, Houston, TX, USA.
10 PERFORM Centre, Concordia University, Montréal, QC, Canada.
11 Department of Oncology, McMaster University, Hamilton, ON, Canada.
12 Department of Radiation Oncology, Toronto, ON, Canada.

Description:

The time-varying effect of radiotherapy after breast-conserving surgery for DCIS.

Breast Cancer Res Treat. 2019 Jul 31;:

Authors: Rakovitch E, Sutradhar R, Hallett M, Thompson AM, Gu S, Dumeaux V, Whelan TJ, Paszat L

Abstract

BACKGROUND: A better understanding underlying radiation (RT) response after breast-conserving surgery (BCS) is needed to mitigate over-treatment of DCIS. The hazard ratio (HR) measures the effect of RT but assumes the effect is constant over time. We examined the hazard function adjusted for adherence to surveillance mammography to examine variations in LR risk and the effect of RT over time.

METHODS: Crude hazard estimates for the development of LR in a population cohort of DCIS treated by BCS?±?RT were computed. Multivariable extended Cox models and hazard plots were used to examine the association between receipt of RT and risk of each outcome adjusted for baseline covariates and adherence to mammography.

RESULTS: Population cohort includes 3262 women treated by BCS; 1635 received RT. Median follow-up was 13 years. LR developed in 364 women treated by BCS alone and 274 treated with RT. LR risk peaked at 2 years, declined until year 7, and then remained steady. The peak hazard of LR was associated with adverse features of DCIS. Early LR risk was attenuated in patients treated with RT but late annual risks of LR and invasive LR were similar among the two treatment groups. On multivariate analysis, RT was associated with a reduction in early LR risk (HR?=?0.52, 95% CI 0.43-0.63, p?<?0.0001) but did not reduce the risk of late LR (HR?=?0.89, 95% CI: 0.67, 1.19, p?=?0.44) (interaction, p?=?0.002).

CONCLUSIONS: The effect of RT is not uniform over time and greatest in the first 7 years after BCS for DCIS, which can guide future research to understand mechanisms underlying RT response and optimize future management of DCIS.

PMID: 31368035 [PubMed - as supplied by publisher]