Keyword search (3,447 papers available)


A Go/No-go delayed nonmatching-to-sample procedure to measure object-recognition memory in rats.

Author(s): Cole E, Chad M, Moman V, Mumby DG

Behav Processes. 2020 Jun 10;:104180 Authors: Cole E, Chad M, Moman V, Mumby DG

Article GUID: 32533993
Effects of perirhinal cortex and hippocampal lesions on rats' performance on two object-recognition tasks.

Author(s): Cole E, Ziadé J, Simundic A, Mumby DG

Behav Brain Res. 2019 Dec 23;:112450 Authors: Cole E, Ziadé J, Simundic A, Mumby DG

Article GUID: 31877339
Assessing object-recognition memory in rats: Pitfalls of the existent tasks and the advantages of a new test.

Author(s): Cole E, Simundic A, Mossa FP, Mumby DG

Learn Behav. 2018 Aug 21;: Authors: Cole E, Simundic A, Mossa FP, Mumby DG

Article GUID: 30132280
Modulatory effect of 17-β estradiol on performance of ovariectomized rats on the Shock-Probe test.

Author(s): Gervais NJ, Jacob S, Brake WG, Mumby DG

Physiol Behav. 2014 May 28;131:129-35 Authors: Gervais NJ, Jacob S, Brake WG, Mumby DG

Article GUID: 24768650
Retrograde and anterograde memory following selective damage to the dorsolateral entorhinal cortex.

Author(s): Gervais NJ, Barrett-Bernstein M, Sutherland RJ, Mumby DG

Neurobiol Learn Mem. 2014 Dec;116:14-26 Authors: Gervais NJ, Barrett-Bernstein M, Sutherland RJ, Mumby DG

Article GUID: 25108197
Attenuation of dendritic spine density in the perirhinal cortex following 17β-Estradiol replacement in the rat.

Author(s): Gervais NJ, Mumby DG, Brake WG

Hippocampus. 2015 Nov;25(11):1212-6 Authors: Gervais NJ, Mumby DG, Brake WG

Article GUID: 26104963
The effects of extrinsic stress on somatic markers and behavior are dependent on animal housing conditions.

Author(s): Huzard D, Mumby DG, Sandi C, Poirier GL, van der Kooij MA

Physiol Behav. 2015 Nov 01;151:238-45 Authors: Huzard D, Mumby DG, Sandi C, Poirier GL, van der Kooij MA

Article GUID: 26220463
Intra-perirhinal cortex administration of estradiol, but not an ERβ agonist, modulates object-recognition memory in ovariectomized rats.

Author(s): Gervais NJ, Hamel LM, Brake WG, Mumby DG

Neurobiol Learn Mem. 2016 09;133:89-99 Authors: Gervais NJ, Hamel LM, Brake WG, Mumby DG

Article GUID: 27321161
Circadian time-place (or time-route) learning in rats with hippocampal lesions.

Author(s): Cole E, Mistlberger RE, Merza D, Trigiani LJ, Madularu D, Simundic A, Mumby DG

Neurobiol Learn Mem. 2016 Dec;136:236-243 Authors: Cole E, Mistlberger RE, Merza D, Trigiani LJ, Madularu D, Simundic A, Mumby DG

Article GUID: 27622983
Title:Effects of perirhinal cortex and hippocampal lesions on rats' performance on two object-recognition tasks.
Authors:Cole E,  Ziadé J,  Simundic A,  Mumby DG
Link:https://www.ncbi.nlm.nih.gov/pubmed/31877339?dopt=Abstract
DOI:10.1016/j.bbr.2019.112450
Category:Behav Brain Res
PMID:31877339
Dept Affiliation: PSYCHOLOGY
1 Department of Psychology, Concordia University, Montréal, QC, Canada. Electronic address: e_cole@live.concordia.ca.
2 Department of Psychology, Concordia University, Montréal, QC, Canada.

Description:

Effects of perirhinal cortex and hippocampal lesions on rats' performance on two object-recognition tasks.

Behav Brain Res. 2019 Dec 23;:112450

Authors: Cole E, Ziadé J, Simundic A, Mumby DG

Abstract

The effects of hippocampal (HPC) damage on rats' novel object preference (NOP) performance have been rather consistent, in that HPC lesions do not disrupt novelty preferences on the test. Conversely, there have been inconsistent findings regarding the effects of perirhinal cortex (PRh) lesions on rats' novel-object preferences. Given the concerns that have been raised regarding the internal validity of the NOP test, viz. that the magnitude of the novel-object preference does not necessarily reflect the strength in memory for an object, it could explain the discrepant findings. The goal of the present experiment was to examine the effects of PRh and HPC lesions on rats' object-recognition memory using a new modified delayed nonmatching-to-sample (mDNMS) task, as it circumvents the interpretational problems associated with the NOP test. Rats received PRh, HPC, or Sham lesions and were trained on the mDNMS task using a short delay (~30?s). Both PRh and HPC rats acquired the task at the same rate as Sham rats, and reached a similar level of accuracy, indicating intact object-recognition. Thereafter, rats were tested on the NOP test using a 180-s delay. Rats with HPC lesions exhibited significant novel-object preferences, however, both the PRh and Sham rats failed to show a novelty preference. The discrepancy in both the PRh and Sham rats' performance on the mDNMS task and NOP test raises concerns regarding the internal validity of the NOP test, in that the magnitude of a rat's novel-object preference does not accurately reflect the persistence or accuracy of a rat's memory for the sample object.

PMID: 31877339 [PubMed - as supplied by publisher]