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A Go/No-go delayed nonmatching-to-sample procedure to measure object-recognition memory in rats.

Author(s): Cole E, Chad M, Moman V, Mumby DG

Behav Processes. 2020 Jun 10;:104180 Authors: Cole E, Chad M, Moman V, Mumby DG

Article GUID: 32533993
Effects of perirhinal cortex and hippocampal lesions on rats' performance on two object-recognition tasks.

Author(s): Cole E, Ziadé J, Simundic A, Mumby DG

Behav Brain Res. 2019 Dec 23;:112450 Authors: Cole E, Ziadé J, Simundic A, Mumby DG

Article GUID: 31877339
Assessing object-recognition memory in rats: Pitfalls of the existent tasks and the advantages of a new test.

Author(s): Cole E, Simundic A, Mossa FP, Mumby DG

Learn Behav. 2018 Aug 21;: Authors: Cole E, Simundic A, Mossa FP, Mumby DG

Article GUID: 30132280
Modulatory effect of 17-β estradiol on performance of ovariectomized rats on the Shock-Probe test.

Author(s): Gervais NJ, Jacob S, Brake WG, Mumby DG

Physiol Behav. 2014 May 28;131:129-35 Authors: Gervais NJ, Jacob S, Brake WG, Mumby DG

Article GUID: 24768650
Retrograde and anterograde memory following selective damage to the dorsolateral entorhinal cortex.

Author(s): Gervais NJ, Barrett-Bernstein M, Sutherland RJ, Mumby DG

Neurobiol Learn Mem. 2014 Dec;116:14-26 Authors: Gervais NJ, Barrett-Bernstein M, Sutherland RJ, Mumby DG

Article GUID: 25108197
Attenuation of dendritic spine density in the perirhinal cortex following 17β-Estradiol replacement in the rat.

Author(s): Gervais NJ, Mumby DG, Brake WG

Hippocampus. 2015 Nov;25(11):1212-6 Authors: Gervais NJ, Mumby DG, Brake WG

Article GUID: 26104963
The effects of extrinsic stress on somatic markers and behavior are dependent on animal housing conditions.

Author(s): Huzard D, Mumby DG, Sandi C, Poirier GL, van der Kooij MA

Physiol Behav. 2015 Nov 01;151:238-45 Authors: Huzard D, Mumby DG, Sandi C, Poirier GL, van der Kooij MA

Article GUID: 26220463
Intra-perirhinal cortex administration of estradiol, but not an ERβ agonist, modulates object-recognition memory in ovariectomized rats.

Author(s): Gervais NJ, Hamel LM, Brake WG, Mumby DG

Neurobiol Learn Mem. 2016 09;133:89-99 Authors: Gervais NJ, Hamel LM, Brake WG, Mumby DG

Article GUID: 27321161
Circadian time-place (or time-route) learning in rats with hippocampal lesions.

Author(s): Cole E, Mistlberger RE, Merza D, Trigiani LJ, Madularu D, Simundic A, Mumby DG

Neurobiol Learn Mem. 2016 Dec;136:236-243 Authors: Cole E, Mistlberger RE, Merza D, Trigiani LJ, Madularu D, Simundic A, Mumby DG

Article GUID: 27622983
Title:A Go/No-go delayed nonmatching-to-sample procedure to measure object-recognition memory in rats.
Authors:Cole E,  Chad M,  Moman V,  Mumby DG
Link:https://www.ncbi.nlm.nih.gov/pubmed/32533993?dopt=Abstract
DOI:10.1016/j.beproc.2020.104180
Category:Behav Processes
PMID:32533993
Dept Affiliation: PSYCHOLOGY
1 Department of Psychology, Concordia University, Montréal, QC, Canada. Electronic address: e_cole@live.concordia.ca.
2 Department of Psychology, Concordia University, Montréal, QC, Canada.

Description:

A Go/No-go delayed nonmatching-to-sample procedure to measure object-recognition memory in rats.

Behav Processes. 2020 Jun 10;:104180

Authors: Cole E, Chad M, Moman V, Mumby DG

Abstract

The novel-object preference (NOP) test is widely used to assess object-recognition memory in rats. When interpreting behaviour on the test, a common assumption is that the magnitude of a rat's novel-object preference reflects the persistence or accuracy of its memory for the previously encountered object. However, some concerns have been raised regarding the latter interpretation, and hence, the internal validity of the NOP test as a gauge of object-recognition abilities. Given the concerns, we developed a new Go/No-go delayed nonmatching-to-sample (DNMS) procedure to measure object-recognition memory, which circumvents the interpretational problems associated with the NOP test. Rats were trained to displace an unfamiliar object (sample) from over a food well to obtain a food reward. Then on a choice phase, rats were presented with novel objects ("Go" trial) or copies of the sample object ("No-go" trial). On Go trials rats received a reward for displacing the novel object and on No-go trials no reward was provided for displacing the sample object. Rats required an average 54 sessions to reach a performance criterion of at least 80% correct choices on five consecutive sessions (16 correct choices out of 20). Afterwards, rats were tested on the NOP test, and we found that scores on both tasks were not significantly correlated, indicating performance on the Go/No-go DNMS task did not predict novelty preference scores. The findings from this experiment reveal the benefits of an alternative approach to assess object-recognition memory in rats.

PMID: 32533993 [PubMed - as supplied by publisher]