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A Go/No-go delayed nonmatching-to-sample procedure to measure object-recognition memory in rats.

Author(s): Cole E, Chad M, Moman V, Mumby DG

Behav Processes. 2020 Jun 10;:104180 Authors: Cole E, Chad M, Moman V, Mumby DG

Article GUID: 32533993
Effects of perirhinal cortex and hippocampal lesions on rats' performance on two object-recognition tasks.

Author(s): Cole E, Ziadé J, Simundic A, Mumby DG

Behav Brain Res. 2019 Dec 23;:112450 Authors: Cole E, Ziadé J, Simundic A, Mumby DG

Article GUID: 31877339
Assessing object-recognition memory in rats: Pitfalls of the existent tasks and the advantages of a new test.

Author(s): Cole E, Simundic A, Mossa FP, Mumby DG

Learn Behav. 2018 Aug 21;: Authors: Cole E, Simundic A, Mossa FP, Mumby DG

Article GUID: 30132280
Modulatory effect of 17-β estradiol on performance of ovariectomized rats on the Shock-Probe test.

Author(s): Gervais NJ, Jacob S, Brake WG, Mumby DG

Physiol Behav. 2014 May 28;131:129-35 Authors: Gervais NJ, Jacob S, Brake WG, Mumby DG

Article GUID: 24768650
Retrograde and anterograde memory following selective damage to the dorsolateral entorhinal cortex.

Author(s): Gervais NJ, Barrett-Bernstein M, Sutherland RJ, Mumby DG

Neurobiol Learn Mem. 2014 Dec;116:14-26 Authors: Gervais NJ, Barrett-Bernstein M, Sutherland RJ, Mumby DG

Article GUID: 25108197
Attenuation of dendritic spine density in the perirhinal cortex following 17β-Estradiol replacement in the rat.

Author(s): Gervais NJ, Mumby DG, Brake WG

Hippocampus. 2015 Nov;25(11):1212-6 Authors: Gervais NJ, Mumby DG, Brake WG

Article GUID: 26104963
The effects of extrinsic stress on somatic markers and behavior are dependent on animal housing conditions.

Author(s): Huzard D, Mumby DG, Sandi C, Poirier GL, van der Kooij MA

Physiol Behav. 2015 Nov 01;151:238-45 Authors: Huzard D, Mumby DG, Sandi C, Poirier GL, van der Kooij MA

Article GUID: 26220463
Intra-perirhinal cortex administration of estradiol, but not an ERβ agonist, modulates object-recognition memory in ovariectomized rats.

Author(s): Gervais NJ, Hamel LM, Brake WG, Mumby DG

Neurobiol Learn Mem. 2016 09;133:89-99 Authors: Gervais NJ, Hamel LM, Brake WG, Mumby DG

Article GUID: 27321161
Circadian time-place (or time-route) learning in rats with hippocampal lesions.

Author(s): Cole E, Mistlberger RE, Merza D, Trigiani LJ, Madularu D, Simundic A, Mumby DG

Neurobiol Learn Mem. 2016 Dec;136:236-243 Authors: Cole E, Mistlberger RE, Merza D, Trigiani LJ, Madularu D, Simundic A, Mumby DG

Article GUID: 27622983
Title:Attenuation of dendritic spine density in the perirhinal cortex following 17β-Estradiol replacement in the rat.
Authors:Gervais NJ,  Mumby DG,  Brake WG
Link:https://www.ncbi.nlm.nih.gov/pubmed/26104963?dopt=Abstract
Category:Hippocampus
PMID:26104963
Dept Affiliation: CSBN
1 Department of Psychology, Center for Studies in Behavioral Neurobiology (CSBN), Concordia University, Montreal, Quebec, Canada.

Description:

Attenuation of dendritic spine density in the perirhinal cortex following 17ß-Estradiol replacement in the rat.

Hippocampus. 2015 Nov;25(11):1212-6

Authors: Gervais NJ, Mumby DG, Brake WG

Abstract

Intraperirhinal cortex infusion of 17-ß estradiol (E2) impairs object-recognition memory. However, it is not currently known whether this hormone modulates synaptic plasticity in this structure. Most excitatory synapses in the central nervous system are located on dendritic spines, and elevated E2 levels influence the density of these spines in several brain areas. The goal of the present study was to determine whether differences in dendritic spine density in the perirhinal cortex are observed following high E2 replacement in ovariectomized rats. The density of total spines, and mushroom-shaped (i.e. mature) spines were compared between a high E2 replacement (10 µg/kg/day, s.c.) and a no replacement condition. The perirhinal cortex is subdivided into Broadmann's area 35 and 36 and so group comparisons were made within each sub-region separately. High E2 replacement resulted in lower density of mushroom-shaped spines in area 35 relative to no replacement. There was no effect of high E2 replacement on dendritic spine density in area 36. These findings are consistent with the idea that higher E2 levels reduce dendritic spine density in area 35, which may result from spine shrinkage, or reduced synapse formation. This study provides preliminary evidence for a mechanism through which E2 may impair object-recognition memory.

PMID: 26104963 [PubMed - indexed for MEDLINE]