Keyword search (3,170 papers available)


A reliable, reproducible flow cytometry protocol for immune cell quantification in human adipose tissue.

Author(s): Delaney KZ, Dam V, Murphy J, Morais JA, Denis R, Atlas H, Pescarus R, Garneau PY, Santosa S...

The ability to accurately identify and quantify immune cell populations within adipose tissue is important in understanding the role of immune cells in metabolic disease risk. Flow cytometry is the...

Article GUID: 32926866
Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity.

Author(s): Tam BT, Murphy J, Khor N, Morais JA, Santosa S

Although childhood-onset obesity (CO) and adult-onset obesity (AO) are known to lead to distinctive clinical manifestations and disease risks, the fundamental differences between them are largely unclear. The aim of the current study is to investigate the f...

Article GUID: 32808657
Obesity and ageing: Two sides of the same coin.

Author(s): Tam BT, Morais JA, Santosa S

Obes Rev. 2020 Feb 05;: Authors: Tam BT, Morais JA, Santosa S

Article GUID: 32020741
Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage.

Author(s): Santosa S, Bush NC, Jensen MD

J Clin Endocrinol Metab. 2017 08 01;102(8):3056-3064 Authors: Santosa S, Bush NC, Jensen MD

Article GUID: 28641384
Intra-Abdominal Adipose Tissue Quantification by Alternative Versus Reference Methods: A Systematic Review and Meta-Analysis.

Author(s): Murphy J, Bacon SL, Morais JA, Tsoukas MA, Santosa S

Obesity (Silver Spring). 2019 May 27;: Authors: Murphy J, Bacon SL, Morais JA, Tsoukas MA, Santosa S

Article GUID: 31131996
Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles.

Author(s): Varady KA, Dam VT, Klempel MC, Horne M, Cruz R, Kroeger CM, Santosa S

Sci Rep. 2015 Jan 05;5:7561 Authors: Varady KA, Dam VT, Klempel MC, Horne M, Cruz R, Kroeger CM, Santosa S

Article GUID: 25557754
The Sexual Dimorphism of Lipid Kinetics in Humans.

Author(s): Santosa S, Jensen MD

Front Endocrinol (Lausanne). 2015;6:103 Authors: Santosa S, Jensen MD

Article GUID: 26191040
From neutrophils to macrophages: differences in regional adipose tissue depots.

Author(s): Dam V, Sikder T, Santosa S

Obes Rev. 2016 Jan;17(1):1-17 Authors: Dam V, Sikder T, Santosa S

Article GUID: 26667065
Acute Female Hypogonadism Alters Adipose Tissue Fatty Acid Storage Factors and Chylomicronemia.

Author(s): Santosa S, Bonnes SL, Jensen MD

J Clin Endocrinol Metab. 2016 05;101(5):2089-98 Authors: Santosa S, Bonnes SL, Jensen MD

Article GUID: 27003301
Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs.

Author(s): Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S

Nutr Res. 2016 May;36(5):408-17 Authors: Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S

Article GUID: 27101759
Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression.

Author(s): Murphy J, Moullec G, Santosa S

Metabolism. 2017 Feb;67:31-40 Authors: Murphy J, Moullec G, Santosa S

Article GUID: 28081776
Regional adiposity and markers of inflammation in pre-school age children.

Author(s): Delaney KZ, Vanstone CA, Weiler HA, Santosa S

Sci Rep. 2018 Oct 12;8(1):15204 Authors: Delaney KZ, Vanstone CA, Weiler HA, Santosa S

Article GUID: 30315178
Meeting fruit and vegetable consumption and physical activity recommendations among adolescents intending to lose weight.

Author(s): Kakinami L, Houle-Johnson SA, Demissie Z, Santosa S, Fulton JE

Prev Med Rep. 2019 Mar;13:11-15 Authors: Kakinami L, Houle-Johnson SA, Demissie Z, Santosa S, Fulton JE

Article GUID: 30456053
Title:Regional adiposity and markers of inflammation in pre-school age children.
Authors:Delaney KZ,  Vanstone CA,  Weiler HA,  Santosa S
Link:https://www.ncbi.nlm.nih.gov/pubmed/30315178?dopt=Abstract
Category:Sci Rep
PMID:30315178
Dept Affiliation: PERFORM
1 Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, Quebec, Canada.
2 Metabolism, Obesity, Nutrition Lab, PERFORM Centre, Concordia University, Montreal, Quebec, Canada.
3 Centre de recherche - Axe maladies chroniques, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, Montréal, PQ, Canada.
4 School of Human Nutrition, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada.
5 Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, Quebec, Canada. s.santosa@concordia.ca.
6 Metabolism, Obesity, Nutrition Lab, PERFORM Centre, Concordia University, Montreal, Quebec, Canada. s.santosa@concordia.ca.
7 Centre de recherche - Axe maladies chroniques, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, Montréal, PQ, Canada. s.santosa@concordia.ca.

Description:

Regional adiposity and markers of inflammation in pre-school age children.

Sci Rep. 2018 Oct 12;8(1):15204

Authors: Delaney KZ, Vanstone CA, Weiler HA, Santosa S

Abstract

In adults, upper body fat partially increases metabolic disease risk through increasing systemic inflammation. Our objective was to determine if this relationship exists in preschool-aged children. A subset of children (n?=?71, 35 males), 3.7?±?1.0?y, were studied from n?=?515 children recruited from randomly selected daycares in Montréal, QC. According to WHO charts for 2-5?y, 49 children were healthy weight (HW) and 21 were overweight (OW). Adiposity was determined through dual-energy x-ray absorptiometry. Blood concentrations of C-reactive protein (CRP) and tumour necrosis factor alpha (TNFa) were determined via enzyme-linked immunosorbent and multiplex assays, respectively. OW children had higher (p?=?0.03) android:gynoid ratio 0.50?±?0.09 compared to HW children 0.56?±?0.12, indicating excess fat was predominantly stored in the abdominal depot. CRP was higher (p?=?0.01) in OW children 1.45?±?2.02?mg/L compared to HW 0.74?±?1.38?mg/L. Percent fat was correlated with CRP (r?=?0.32; p?<?0.01) and TNFa (r?=?0.25; p?=?0.04) concentrations. CRP also correlated with android adiposity (r?=?0.24; p?=?0.04) and TNFa correlated with gynoid adiposity (r?=?0.24; p?=?0.04). We observed that greater adiposity is associated with higher systemic inflammation in pre-school aged children. Future longitudinal studies are needed to understand the long term consequences of excess total and regional body fat in young children.

PMID: 30315178 [PubMed - in process]