Keyword search (3,170 papers available)


A reliable, reproducible flow cytometry protocol for immune cell quantification in human adipose tissue.

Author(s): Delaney KZ, Dam V, Murphy J, Morais JA, Denis R, Atlas H, Pescarus R, Garneau PY, Santosa S...

The ability to accurately identify and quantify immune cell populations within adipose tissue is important in understanding the role of immune cells in metabolic disease risk. Flow cytometry is the...

Article GUID: 32926866
Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity.

Author(s): Tam BT, Murphy J, Khor N, Morais JA, Santosa S

Although childhood-onset obesity (CO) and adult-onset obesity (AO) are known to lead to distinctive clinical manifestations and disease risks, the fundamental differences between them are largely unclear. The aim of the current study is to investigate the f...

Article GUID: 32808657
Obesity and ageing: Two sides of the same coin.

Author(s): Tam BT, Morais JA, Santosa S

Obes Rev. 2020 Feb 05;: Authors: Tam BT, Morais JA, Santosa S

Article GUID: 32020741
Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage.

Author(s): Santosa S, Bush NC, Jensen MD

J Clin Endocrinol Metab. 2017 08 01;102(8):3056-3064 Authors: Santosa S, Bush NC, Jensen MD

Article GUID: 28641384
Intra-Abdominal Adipose Tissue Quantification by Alternative Versus Reference Methods: A Systematic Review and Meta-Analysis.

Author(s): Murphy J, Bacon SL, Morais JA, Tsoukas MA, Santosa S

Obesity (Silver Spring). 2019 May 27;: Authors: Murphy J, Bacon SL, Morais JA, Tsoukas MA, Santosa S

Article GUID: 31131996
Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles.

Author(s): Varady KA, Dam VT, Klempel MC, Horne M, Cruz R, Kroeger CM, Santosa S

Sci Rep. 2015 Jan 05;5:7561 Authors: Varady KA, Dam VT, Klempel MC, Horne M, Cruz R, Kroeger CM, Santosa S

Article GUID: 25557754
The Sexual Dimorphism of Lipid Kinetics in Humans.

Author(s): Santosa S, Jensen MD

Front Endocrinol (Lausanne). 2015;6:103 Authors: Santosa S, Jensen MD

Article GUID: 26191040
From neutrophils to macrophages: differences in regional adipose tissue depots.

Author(s): Dam V, Sikder T, Santosa S

Obes Rev. 2016 Jan;17(1):1-17 Authors: Dam V, Sikder T, Santosa S

Article GUID: 26667065
Acute Female Hypogonadism Alters Adipose Tissue Fatty Acid Storage Factors and Chylomicronemia.

Author(s): Santosa S, Bonnes SL, Jensen MD

J Clin Endocrinol Metab. 2016 05;101(5):2089-98 Authors: Santosa S, Bonnes SL, Jensen MD

Article GUID: 27003301
Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs.

Author(s): Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S

Nutr Res. 2016 May;36(5):408-17 Authors: Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S

Article GUID: 27101759
Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression.

Author(s): Murphy J, Moullec G, Santosa S

Metabolism. 2017 Feb;67:31-40 Authors: Murphy J, Moullec G, Santosa S

Article GUID: 28081776
Regional adiposity and markers of inflammation in pre-school age children.

Author(s): Delaney KZ, Vanstone CA, Weiler HA, Santosa S

Sci Rep. 2018 Oct 12;8(1):15204 Authors: Delaney KZ, Vanstone CA, Weiler HA, Santosa S

Article GUID: 30315178
Meeting fruit and vegetable consumption and physical activity recommendations among adolescents intending to lose weight.

Author(s): Kakinami L, Houle-Johnson SA, Demissie Z, Santosa S, Fulton JE

Prev Med Rep. 2019 Mar;13:11-15 Authors: Kakinami L, Houle-Johnson SA, Demissie Z, Santosa S, Fulton JE

Article GUID: 30456053
Title:Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage.
Authors:Santosa S,  Bush NC,  Jensen MD
Link:https://www.ncbi.nlm.nih.gov/pubmed/28641384?dopt=Abstract
Category:J Clin Endocrinol Metab
PMID:28641384
Dept Affiliation: HKAP
1 Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905.
2 Department of Exercise Science, Concordia University, Montreal, Quebec H4B 1R6, Canada.

Description:

Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage.

J Clin Endocrinol Metab. 2017 08 01;102(8):3056-3064

Authors: Santosa S, Bush NC, Jensen MD

Abstract

Context: Although the long-term effects of testosterone on adipose tissue lipid metabolism in men have been defined, the short-term regulation of these effects is not well understood.

Objective: We examined the effects of acute testosterone withdrawal on subcutaneous abdominal and femoral adipose tissue fatty acid (FA) storage and cellular mechanisms.

Design: This was a prospective, randomized trial.

Setting: Mayo Clinic Clinical Research Unit.

Patients or Participants: Thirty-two male volunteers ages 18 to 50 participated in these studies.

Interventions: Volunteers were randomized to receive (1) no treatment (control), (2) injections (7.5 mg) of Lupron®, or (3) Lupron and testosterone (L+T) replacement for 49 days, resulting in 4 weeks of sex steroid suppression in the Lupron group.

Main Outcome Measures: We measured body composition, fat cell size, adipose tissue meal FA and direct free FA storage, lipoprotein lipase (LPL), acyl coenzyme A synthetase (ACS), diacylglycerol acyltransferase activities, and CD36 content.

Results: Compared with control and L+T groups, acute testosterone deficiency resulted in greater femoral adipose tissue meal FA storage rates, fasting and fed LPL activity, and ACS activity.

Conclusions: These results suggest that in men, testosterone plays a tonic role in restraining FA storage in femoral adipose tissue via suppression of LPL and ACS activities. FA storage mechanisms in men appear sensitive to short-term changes in testosterone concentrations.

PMID: 28641384 [PubMed - indexed for MEDLINE]