Keyword search (3,170 papers available)


A reliable, reproducible flow cytometry protocol for immune cell quantification in human adipose tissue.

Author(s): Delaney KZ, Dam V, Murphy J, Morais JA, Denis R, Atlas H, Pescarus R, Garneau PY, Santosa S...

The ability to accurately identify and quantify immune cell populations within adipose tissue is important in understanding the role of immune cells in metabolic disease risk. Flow cytometry is the...

Article GUID: 32926866
Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity.

Author(s): Tam BT, Murphy J, Khor N, Morais JA, Santosa S

Although childhood-onset obesity (CO) and adult-onset obesity (AO) are known to lead to distinctive clinical manifestations and disease risks, the fundamental differences between them are largely unclear. The aim of the current study is to investigate the f...

Article GUID: 32808657
Obesity and ageing: Two sides of the same coin.

Author(s): Tam BT, Morais JA, Santosa S

Obes Rev. 2020 Feb 05;: Authors: Tam BT, Morais JA, Santosa S

Article GUID: 32020741
Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage.

Author(s): Santosa S, Bush NC, Jensen MD

J Clin Endocrinol Metab. 2017 08 01;102(8):3056-3064 Authors: Santosa S, Bush NC, Jensen MD

Article GUID: 28641384
Intra-Abdominal Adipose Tissue Quantification by Alternative Versus Reference Methods: A Systematic Review and Meta-Analysis.

Author(s): Murphy J, Bacon SL, Morais JA, Tsoukas MA, Santosa S

Obesity (Silver Spring). 2019 May 27;: Authors: Murphy J, Bacon SL, Morais JA, Tsoukas MA, Santosa S

Article GUID: 31131996
Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles.

Author(s): Varady KA, Dam VT, Klempel MC, Horne M, Cruz R, Kroeger CM, Santosa S

Sci Rep. 2015 Jan 05;5:7561 Authors: Varady KA, Dam VT, Klempel MC, Horne M, Cruz R, Kroeger CM, Santosa S

Article GUID: 25557754
The Sexual Dimorphism of Lipid Kinetics in Humans.

Author(s): Santosa S, Jensen MD

Front Endocrinol (Lausanne). 2015;6:103 Authors: Santosa S, Jensen MD

Article GUID: 26191040
From neutrophils to macrophages: differences in regional adipose tissue depots.

Author(s): Dam V, Sikder T, Santosa S

Obes Rev. 2016 Jan;17(1):1-17 Authors: Dam V, Sikder T, Santosa S

Article GUID: 26667065
Acute Female Hypogonadism Alters Adipose Tissue Fatty Acid Storage Factors and Chylomicronemia.

Author(s): Santosa S, Bonnes SL, Jensen MD

J Clin Endocrinol Metab. 2016 05;101(5):2089-98 Authors: Santosa S, Bonnes SL, Jensen MD

Article GUID: 27003301
Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs.

Author(s): Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S

Nutr Res. 2016 May;36(5):408-17 Authors: Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S

Article GUID: 27101759
Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression.

Author(s): Murphy J, Moullec G, Santosa S

Metabolism. 2017 Feb;67:31-40 Authors: Murphy J, Moullec G, Santosa S

Article GUID: 28081776
Regional adiposity and markers of inflammation in pre-school age children.

Author(s): Delaney KZ, Vanstone CA, Weiler HA, Santosa S

Sci Rep. 2018 Oct 12;8(1):15204 Authors: Delaney KZ, Vanstone CA, Weiler HA, Santosa S

Article GUID: 30315178
Meeting fruit and vegetable consumption and physical activity recommendations among adolescents intending to lose weight.

Author(s): Kakinami L, Houle-Johnson SA, Demissie Z, Santosa S, Fulton JE

Prev Med Rep. 2019 Mar;13:11-15 Authors: Kakinami L, Houle-Johnson SA, Demissie Z, Santosa S, Fulton JE

Article GUID: 30456053
Title:Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs.
Authors:Yang SQ,  DeGuire JR,  Lavery P,  Mak IL,  Weiler HA,  Santosa S
Link:https://www.ncbi.nlm.nih.gov/pubmed/27101759?dopt=Abstract
Category:Nutr Res
PMID:27101759
Dept Affiliation: PERFORM
1 School of Dietetics and Human Nutrition, McGill University, Montreal, QC H9X 3V9, Canada.
2 Department of Exercise Science, Concordia University, Montreal, QC H4B 1R6, Canada; Nutrition, Obesity and Metabolism Lab, PERFORM Centre, Concordia University, Montreal, QC H4B 1R6, Canada. Electronic address: s.santosa@concordia.ca.

Description:

Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs.

Nutr Res. 2016 May;36(5):408-17

Authors: Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S

Abstract

We hypothesize that conjugated linoleic acid (CLA) may be effective in preventing the changes in total and regional body composition and increases in interleukin (IL) 6 that occur as a result of hypogonadism. Male guinea pigs (n = 40, 70- to 72-week retired breeders) were block randomized by weight into 4 groups: (1) sham surgery (SHAM)/control (CTRL) diet, (2) SHAM/conjugated linoleic acid (CLA) diet (1%), (3) orchidectomy (ORX)/CTRL diet, and (4) ORX/CLA diet. Dual-energy x-ray absorptiometry scans were performed at baseline and week 16 to assess body composition. Serum IL-6 was analyzed using an enzyme-linked immune sorbent assay. Fatty acids (FAs) from visceral and subcutaneous adipose tissue were analyzed using gas chromatography. In ORX/CTRL guinea pigs, percent total body fat increased by 6.1%, and percent lean mass decreased by 6.7% over the 16-week treatment period, whereas no changes were observed for either parameter in ORX/CLA guinea pigs. Guinea pigs fed the CLA diet gained less percent total, upper, and lower body fat than those fed the CTRL diet regardless of surgical treatment. Regional adipose tissue FA composition was reflective of dietary FAs. Serum IL-6 concentrations were not different among groups. In this study, we observed that, in male guinea pigs, hypogonadism resulted in increased fat mass and decreased lean mass. In addition, CLA was effective in reducing gains in body fat and maintaining lean mass in both hypogonadal and intact guinea pigs.

PMID: 27101759 [PubMed - indexed for MEDLINE]